Professor Richard Shaw
Consultant Oral & Maxillofacial / Head & Neck Surgeon
I am an academic Oral & Maxillofacial Surgeon specializing in head and neck cancer and reconstruction. I graduated from the Universities in Bristol and Glasgow with primary degrees in dentistry and medicine. After surgical training in Glasgow, I undertook higher training in OMFS and a head & neck oncology fellowship. Integrated within this clinical training, I completed my MD research thesis in the University of LIverpool as a RCSEng Research Fellow, as well as DoH Genetics in Healthcare Fellowship at MD Anderson Cancer Centre USA. I was appointed to Liverpool University and Aintree in 2007, gaining a personal chair in 2012. I am the chair of the Mersey Head & Neck Oncology Group (MHNORG), the research arm of Liverpool Head & Neck Centre. MHNORG is an expanding and vibrant multidisciplinary collaboration of clinicians and scientists committed to improving understanding and treatment of malignancies of the mouth, throat and larynx.
My clinical role is as a head and neck surgeon specialising in oral cavity, microvascular reconstruction, osteoradionecrosis and premalignancy. I have innovated in composite, chimeric and perforator free flaps, sentinel node biopsy and the management of oral dysplasia and lead several multicentre randomised controlled trials.
I lead the University of Liverpool MSc in Oral & Maxillofacial Surgery, initiated in 2010. This masters pathway has five specialty modules, of which I lead two, reflecting the breadth of the OMFS curriculum.
Following several senior roles in the NCRI Clinical Studies Groups, I was appointed as an associate director of NIHR CRN(Cancer) 2014-2021 with specific remit for advancing surgical oncology trials and the role of surgeons in the national cancer portfolio. I am president elect of the International Academy of Oral Oncology 2023, and I chair the H&N Cancer arm of the COVIDSurg collaborative.
My main research interests are currently:
Premalignancy, prevention and early detection of oral cancer
Late effects, particularly late radiation toxicities such as mandibular osteoradionecrosis
COVIDSurg – the impact of the pandemic on head and neck cancer, and cancer surgery
Insight into metastatic oral cancer tissue from novel analyses using FTIR spectroscopy and aperture IR-SNOM. Analyst, 2021, 146, 4895. DOI: 10.1039/d1an00922b
Head and neck cancer surgery during the COVID-19 pandemic: an international, multicentre, observational cohort study. COVIDSurg Collaborative. Cancer; 2020 doi. 10.1002/cncr.33320 (corresponding author)
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study. COVIDSurg Collaborative. J Clin Oncol. 2020 doi: 10.1200/JCO.20.01933
Guidelines for cellular and molecular pathology content in clinical trial protocols: the SPIRIT-Path extension. SPIRIT-Path collaborative. Lancet Oncology October, 2021 DOI:https://doi.org/10.1016/S1470-2045(21)00344-2
SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaestheisa 2021 Aug 24. doi: 10.1111/anae.15563. COVIDSurg Collaborative
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. COVIDSurg Collaborative. Lancet. 2020 Jul 4;396(10243):27-38. doi: 10.1016/S0140-6736(20)31182-X
Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy. Sci Rep. 2019 Aug 19;9(1):11992. doi: 10.1038/s41598-019-48229-7
HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomized Controlled Trial of Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible After Dentoalveolar Surgery. M. Int J Radiat Oncol Biol Phys. 2019 Jul 1;104(3):530-539. doi: 10.1016/j.ijrobp.2019.02.044.
HPV-related oropharyngeal cancer in the United Kingdom: an evolution in understanding of disease etiology. Cancer Res. 2016 Aug 28. pii: canres.0633.2016.
A new classification for the mandible defect based on a systematic review of segmental resection and composite microvascular reconstruction. Lancet Oncol. 2016 Jan;17(1):e23-30. doi: 10.1016/S1470-2045(15)00310-1.
Chief Investigator: NIHR131050 “RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis” NIHR EME: £1,004,830 Feb 2021
Chief Investigator: NIHR/MRC EME : “SAVER - Sodium Valproate for Epigenetic Reprogramming in the Management of High Risk Oral Epithelial Dysplasia” £1,069,150, 2019-2022
CRUK 165638: CRUK - Early detection of oral cancer using infrared imaging £430,600 C7738/A26196 Early Detection Committee - Project Award Early detection of oral cancer using infrared imaging PI P Weightman, R Shaw, J M Risk (Co-applicant)
NIHR RFPB: Research for Patient Benefit Programme: (2016-2019) PentoxIfylline and Tocopherol for the treatment of poST radiotherapy fibrOsis in head and neck cancer Patients: a feasibility study (PIT- STOP) (Co-Investigator) £252,210
Pathos -T: A Bioresource Collection associated with PATHOS, a Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer. P I Jones T M £397,251
Professor Peter Weightman, Department of Physics, University of Liverpool
Professor Stefano Fedele, Oral Medicine, UCL
Professor Tas Kanatas, OMFS, University of Leeds
NCRI H&N Group
European Sentinel Lymph Node in HN Collaborative