Liverpool Head & Neck Centre

Séamus Coyle

Dr Séamus Coyle

Consultant in Palliative Medicine, Research lead for palliative and supportive care at Clatterbridge and an Honorary Senior Clinical Lecturer at the University of Liverpool.

Before studying Medicine he completed a BSc in Biotechnology, a Masters in Medical Sciences and a PhD. He studied Medicine at the National University of Ireland Medical School in Galway and graduated in 2006. He moved to Liverpool to take up an Academic Clinical Fellowship in August 2012 and completed consultancy training in 2016.  He worked as a community palliative care consultant in St Helens and Knowsley from 2017 – 2020 prior to joining Clatterbridge June 2021. . He is the research lead for the ‘Biology of Dying’ project. A project dedicated to understanding the biology of dying and developing tests recognising the dying process.

His main research area is the Biology of dying that he has been working on since 2012. He is also passionate about trying to improve treatments to control symptoms.

  • Original

    • Aggarwal P, Baker J, Boyd MT, Coyle S, Probert P, Chapman EA Optimisation of urine sample preparation for headspace-solid phase microextraction gas chromatography-mass spectrometry: altering sample pH, sulphuric acid concentration and phase ratio. Metabolites 202010(12), 482;

    • Coyle S, Monnery D Improved analgesia by correction of hypomagnesaemia? BMJ Supportive & Palliative Care Published Online First: 14 June 2018. doi: 10.1136/bmjspcare-2018-001565

    • Coyle S, Scott A, Nwosu A, Latten R, Wilson J, Mayland CR, Mason S, Probert C, Ellershaw JE Collection of biological material from patients towards the end of life BMJ Open 2016, 6. e011763. doi:10.1136/bmjopen-2016-011763 

    • Aggio R MA, Coyle S, Reade S, Khalid T, Ratcliffe N, Probert C Freeze-drying for the analysis of volatile organic compounds in the headspace of urine samples using solid phase micro-extraction coupled to gas chromatography – mass spectrometry Chemistry Central 10:9 DOI: 10.1186/s13065-016-0155-2. (

    • Sweeney C, Morrow D, Birney YA, Coyle S, Hennessy C, Scheller A, Cummins PM, Walls D, Redmond EM, Cahill PA (2004) Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. FASEB J. Sep;18(12):1421-3.

    • O'Loughlin C, Heenan M, Coyle S and Clynes M. (2000) Altered cell cycle response of drug-resistant lung carcinoma cells to doxorubicin European Journal of Cancer 36: 1149-1160.

    • Duffy CP, Elliott CJ, O’Connor RA, Heenan MH, Coyle S, Cleary IM, Kavanagh K, Verhaegen S, O’Loughlin CM, NicAmhlaoibh R and Clynes M. (1998) Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a sub-set of non-steroidal anti-inflammatory drugs (NSAIDs). European Journal of Cancer 34: 1250-1259.

    • Daly C, Coyle S, McBride S, O'Driscoll L, Daly N, Scanlon K and Clynes M. (1996) mdr1 ribozyme mediated reversal of the multidrug resistant phenotype in human lung cell lines. Cytotechnology 19: 199-205.


    • Reid VL MR, Nwosu AC, Mason SR, Probert C, Ellershaw JE, Coyle S A Systematically Structured Review of Biomarkers of Dying in Cancer Patients in the Last Months of Life; an Exploration of Potential Prognostic Indicators published 06 Apr 2017 PLOS ONE 

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    • Verhaegen S, Coyle S, Connolly L, O’Loughlin C and Clynes M. (1998) Analysis of cell cycle and cell death mechanisms. (chapter in) Animal Cell Culture Techniques (Ed. Clynes M.) Springer-Verlag.


    • Chapman E, Coyle S Predicting the last days of life will change clinical practice BMJ Supportive & Palliative Care 2020 (

    • Coyle S, Elverson J, Harlow T, Jordan A, McNamara P, O'Neill C, Quibell R, Regnard C, Spiller J, Stephenson J. The myth that shames us all.  Lancet 2018; 392(1054): 1196

    Submitted for publication

    • Coyle S, Monnery D, Benson S, Wignall-Coyle J., Powell P (2021) Anticipatory CSCI prescribing and administration in the community – is it safe? BMJ Supportive & Palliative Care 2020 (accepted)

    • Monnery D, Benson S, Wong H, Olsen-Brown A, Coyle S (2021) Less Chemotherapy for equal survival: a case-control study of enhanced supportive care in hepatobiliary cancer.

    • Wellcome Trust Seed award for Science ‘Biology of Dying’ October 2017 – September 2019 £99,287 (Principal Investigator)

    • North West Cancer Research ‘Method optimisation of urine GC-MS analysis to predict dying in lung cancer patients’ Aug 2019 - Jan 2020 £33,989.70 (Principal Investigator)

    • University of Liverpool, Technology  directorate, “The  Biology  of  Dying” May-November 2019 £2,499 (Co-applicant with the Computational Biology Facility)