Liverpool Head & Neck Centre
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Jason Fleming

Jason Fleming

Senior Clinical Lecturer/Honorary Consultant Head & Neck Surgeon

I am an academic ENT/Head & Neck Surgeon, specialising in head and neck cancer and thyroid surgery. I am a Senior Clinical Lecturer at the University of Liverpool and an active member of the Mersey Head & Neck Oncology Group (MHNORG), the research arm of Liverpool Head & Neck Centre (LHNC). I have a strong passion for improving patient care through embedded translational and clinical research, with a particular interest in 1) developing and evaluating novel cancer therapies 2) the dysregulation of tumour metabolism and the possibilities this offers for diagnosis and targeting and 3) understanding the immune biology of head and neck cancer. I am the Co-chief Investigator for the upcoming national phase III trial PROTIS (PROton beam Therapy versus Intensity-modulated radiotherapy for Sinonasal cancer), the lead author for the new national UK guidelines for sinonasal malignancy, and head up a number of translational and clinical outcome based projects within LHNC. 

I have an active teaching portfolio within the University of Liverpool, lecturing on a variety of University Masters modules (Frontiers in cancer, Cancer Clinical Trials). On a regional level I am an academic representative for the regional training committee, a member of the pan-Trust surgical robotic steering group and the Fellowship Director for the internationally renowned Shaun Jackson Head and Neck Surgical Fellowship at Aintree.

  • Imperial College, London

    BSc

    2003

    Surgical Sciences

    Imperial College, London

    MBBS

    2005

    Medicine

    Imperial College, London

    MEd

    2010

    Surgical Education

    University of Southampton

    PhD

    2017

    Cancer biology

    South Thames (London)

    Higher surgical training (residency)

    2018

    Otolaryngology

    Guy’s & St Thomas’, London

    Fellowship

    2019

    Head & Neck/Thyroid Surgical Oncology (TIG)

    UAB-Birmingham, AL, USA

    Fellowship 

    2020

    Ablative & Reconstructive Head & Neck/Thyroid Surgery

  • Realising novel radiosensitisation treatment strategies utilising tumour metabolism in head and neck cancer

    Funder: Royal College of Surgeons (Eng)
    Start date 29/4/2021   
    Duration: 24 months       
    Value: £7,000

    Development of nanoparticle therapeutics in head and neck cancer

    Funder: Institute of Systems, Molecular and Integrative Biology (ISMIB), University of Liverpool
    Start date 1/4/2022    
    Duration: 4 months        
    Value: £5,000

    PROTIS: A phase III trial of proton beam therapy versus intensity-modulated radiotherapy for the treatment of sinonasal malignancy

    Funder: The Taylor Family Foundation/CRUK
    Start date April 2022   
    Duration: 8.5 years       
    Value: ~ £2.1 million

  • PROTIS: A phase III trial of proton beam therapy versus intensity modulated radiotherapy for the treatment of sinonasal malignancy

    Start Date: April 2022
    Completion Date: September 2010
    Recruitment Status: Not yet recruiting

    Summary: Open-label multi-centre prospective phase III randomised controlled trial. The study population is loco-regionally advanced, non-metastatic sinonasal cancer (AJCC 8th edition: Stage III-IVA/B tumours). 

    Head and neck lymphoedema patient reported outcomes (HNL-PRO)

    Start Date: February 2022
    Completion Date: December 2022
    Recruitment Status: Recruiting

    Summary: Qualitative study on patient experience with swelling (lymphoedema) after head and neck cancer treatment

    Patient experience of head and neck cancer treatment across multiple sites within a tertiary care unit (PE-HaNC)

    Start date: April 2021
    Completion Date: April 2022
    Recruitment Status: Recruiting

    Summary: Qualitative study to determine the experiences of head and neck cancer patients treated with multimodality therapy in a hub and spoke care model (surgical treatment at Liverpool Head and Neck Centre and post-operative radiotherapy (PORT) +/- chemoradiotherapy (POCRT) at Clatterbridge Centre). 

  • PhD candidates:            
    Miss. Aderonke Abah
    Dr. Heather Starmer

    MPhil candidates:            
    Mr. Matthew Zammit

    Academic Foundation years:    
    Dr. Randa Ghazal-Asswad
    Dr. Nurhan Abbud

    Fellowship: Director for the Shaun Jackson Head and Neck/Thyroid Fellowship at Aintree

  • Peer-reviewed articles

    1. Garas G, Roland NJ, Lancaster J, Zammit M, Manon VA, Davies K, Jones TM, De M, Holsinger FC, Prestwich RJD, Fleming JC, 2022. Novel Strategies for Managing Retropharyngeal Lymph Node Metastases in Head and Neck and Thyroid Cancer with Transoral Robotic Surgery (TORS). Ann Surg Oncol; doi: 10.1245/s10434-022-12208-6. Online ahead of print. PMID: 35842533

    2. Starmer H, Cherry MG, Patterson J, Young B, Fleming J, 2022. Assessment of Measures of Head and Neck Lymphedema Following Head and Neck Cancer Treatment: A Systematic Review. Lymphat Res Biol; doi: 10.1089/lrb.2021.0100. Online ahead of print. PMID: 35679595

    3. Jones GH, Chudek D, Davies K, Upile N, Kinshuk A, Triantafyllou A, Fleming JC*, Roland NJ* (*joint senior authors), 2022. Lateral cystic neck masses in adults: a ten-year series and comparative analysis of diagnostic modalities. J Laryngol Otol 17:1-26. PMID: 35172908

    4. Iyizoba-Ebozue Z, Fleming JC*, Prestwich RJD*, Thomson DJ (*joint senior authors), 2022. Management of sinonasal cancers: Survey of UK practice and literature overview. Eur J Surg Oncol;48(1):32-43. PMID: 34840009

    5. Hicks MD, Ovaitt AK, Fleming JC, Sorace AG, Song PN, Mansur A, Hartman YE, Rosenthal EL, Warram JM, Thomas CM, 2021. Hyperintensity of integrin-targeted fluorescence agent IntegriSense750 accurately predicts flap necrosis compared to indocyanine green. Head Neck; 44(1):134-142. PMID: 34697855

    6. COVIDSurg Collaborative, 2021. Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic. Br J Surg; 108(1):88-96. PMID: 33640908

    7. Slevin F, Pan S, Mistry H, Denholm M, Shor D, Oong Z, Price J, Jadon R, Fleming JC, Barnett G, Dixon L, Prestwich R, Thomson D, 2021. A multicentre UK study of outcomes for locally advanced sinonasal squamous cell carcinoma treated with adjuvant or definitive intensity modulated radiotherapy. J Clin Oncol; S0936-6555(21)00215-6 [online ahead of print]. PMID: 34147323

    8. Marshall R, Alexander D, Fleming J, Grayson J, Peters G, Buczek E, 2021. Utility of intraoperative frozen sections of thyroid tissue in the age of molecular testing. Clin Otolaryngol [online ahead of print]. PMID: 33811452

    9. Fleming JC, Fuson AR, Jeyarajan H, Thomas CM, Greene B, 2020. Use of a sternocleidomastoid muscle flap to protect the carotid artery during laryngectomy. J Laryngol Otol; 135(6):547-550. PMID: 33975660

    10. Fleming JC, Woo J, Moutasim K, Hanley CJ, Frampton SJ, Wood O, Ward M, Woelk CH, Ottensmeier CH, Hafizi S, Kim D, Thomas GJ, 2020. CTEN Induces Tumour Cell Invasion and Survival and is Prognostic in Radiotherapy-Treated Head Neck Cancer. Cancers (Basel); 12(10), 2963. PMID: 33066224

    11. Glasbey JC, Bhangu A, COVIDSurg Collaborative, 2020. Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study. J Clin Oncol; JCO2001933. PMID: 33021869

    12. COVIDSurg Collaborative, 2020. Delaying surgery for patients with a previous SARS-CoV-2 infection. Br J Surg; Online ahead of print. PMID: 32974904

    13. Ellis M, Garas G, Hardman J, Khan M, Mehanna H, Smith ME, Tikka T, Ubayasiri K, Williams R, INTEGRATE (UK ENT Trainee Research Network), 2020. Post-treatment head and neck cancer care: National audit and analysis of current practice in the United Kingdom. Clin Otolaryngol; Online ahead of print. PMID: 32734679 

    14. Fleming JC, Morley I, Malik M, Orfaniotis G, Daniel C, Townley WA, Jeannon JP, 2020. Orbital exenteration and reconstruction in a tertiary UK institution: a 5-year experience. Orbit; 16:1-10. PMID: 32543976

    15. Fleming JC, Jeannon JP, 2020. Head and neck cancer in the digistal age: an evaluation of mobile health applications. BMJ Innov; 6:13-17.

    16. Fleming JC, Woo J, Moutasim K, Mellone M, Frampton SJ, Mead A, Ahmed W, Wood O, Robinson H, Ward M, Woelk C, Ottensmeier CH, King E, Kim D, Blaydes JP, Thomas GJ, 2019. HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma. Br J Cancer; 120: 356-367. PMID: 30655616

    17. Leow J, Fleming J, Oakley R, 2018. A case series on the conservative management of the bony skull in patients with aggressive skin carcinomas of the scalp. J Surg Case Rep; 11(12):rjy326. PMID: 30555672

    18. Khan AM, Fleming JC, Jeannon JP, 2018. Penetrating neck injuries. Br J Hosp Med (Lond) 2;79(2):72-78. PMID: 29431496

    19. Stephenson KA, Cavalli L, Lambert A, Fleming J, Lawes E, Gupta S, Jephson CG, Cochrane LA, 2017. Paediatric injection medialization laryngoplasty: Recent Great Ormond Street Hospital experience. Int J Pediatr Otorhinolaryngol 100:86-90 PMID 28802393

    20. Ottensmeier CH, Perry KL, Harden EL, Stasakova J, Jenei V, Fleming J, Wood O, Woo J, Woelk CH, Thomas GJ, Thirdborough SM, 2016. Upregulated glucose metabolism correlates inversely with CD8+ T-cell infiltration and survival in squamous cell carcinoma. Cancer Res 15;76(14):4136-48. PMID: 27206847 

    21. Addison AB, Watts S, Fleming J, 2015. Effective communication between ENT and primary care - a survey and analysis of outpatient correspondence structure. Clin Otolaryngol 40(3):191-6. PMID: 25346183

    22. Moore AM, Fleming JC, 2015. Metastatic breast carcinoma presenting as unilateral pulsatile tinnitus: a case report. Ear Nose Throat J; 94(2):E6-8. PMID: 25651358 

    23. Kishikova L, Fleming JC, 2014. Oral feeding following laryngectomy: Early or delayed? Int J Surg 12(11):1137-40. PMID: 25218466

    24. Bowles P, Young P, Das P, Saunders N, Harries M, Fleming JC, 2014. A validation study on the use of intra-operative video recording as an objective assessment tool for core ENT surgery. Clin Otolaryngol 39(2):102-7. PMID: 24712984

    25. Fleming JC, Watts SJ, 2014. The use of a novel post-nasal space pack in routine nasal surgery. Clin Otolaryngol; 39(1):72. PMID: 24575930 

    26. Kishikova L, Smith M, Fleming JC, O’Connell M, 2013. Analgesic regimen and readmission following tonsillectomy. IJOHNS 2(4):121-5. doi: 10.4236/ijohns.2013.24026 

    27. Fleming JC, Al-Radhi Y, Kurian A, Mitchell DB, 2013. A comparative study of flexible nasoendoscopic and rigid endoscopic examination for patients with upper aerodigestive tract symptoms. J Laryngol Otol 127(10):1012-6. PMID: 24067126

    28. Fleming JC, Maskell S, Saunders N, 2012. Simulated procedure-based assessments in temporal bone dissection. Clin Otolaryngol 37:498–499. PMID: 23253347

    29. Fleming JC, Kapoor K, Sevdalis, N, Harries M, 2012. Validation of an OR-based immersive microlaryngoscopy simulator. Laryngoscope 122(5):1099-1103. PMID: 22447525

    30. Fleming JC, 2012.  Portfolios and their role in revalidation and assessment.  Ann R Coll Surg Engl (Suppl) 94(3):1-3. doi: 10.1308/147363512X13189526438035

    31. Morris S, Fleming JC, Harries M, Child C, 2012. Anaesthesia for thyroplasty. JAP 1:17-18

    32. Nayar M, Fleming JC, Wong R, 2011. Preoperative sleep studies for pediatric adenotonsillectomy (abstract). Otolaryngol Head Neck Surg 145(2[suppl]):244

    33. Iacovou E, Nayar M, Fleming JC, Lew-Gor S, 2011. A pain in the neck: a rare case of isolated hyoid bone trauma. JSCR 7:3. PMID: 24950041

    34. Fleming JC, Gibbins N, Ingram PJ, Harries M, 2011. An anatomical study of the myelination of human laryngeal nerves. J Laryngol Otol 125(12):1263-7. PMID: 21854693

    35. Hutson KH, Fleming JC, McGilligan JA, 2011. Just a simple case of tonsillitis? Lemierre’s Syndrome and thrombosis of the external jugular vein. JSCR 4:6. PMID: 24950577

    36. Fleming JC, Black IM, 2010. Current issues in surgical education and recommendations for future training. Ann R Coll Surg Engl (Suppl) 92(6):204-7. doi: 10.1308/147363510X504065

    37. Fleming JC, Mitchell DB, 2009. Response to Raychowdhury & Mukherjee.  Clin Otolaryngol 34(6):578-9. doi: 10.1111/j.1749-4486.2009.02043.x 

    38. Al-reefy H, Fleming J, Mitchell D, 2009. Re: Tonsillectomy and adenoidectomy in children with sleep related breathing disorders: consensus statement of a UK multidisciplinary working party. Clin Otolaryngol 34:493. PMID: 19793288

    39. Fleming JC, Mitchell DB, 2009. Re: Trends in operative training opportunities for junior and senior trainees in otolaryngology. Clin Otolaryngol 34(4):390. PMID: 19673993

    40. Fleming JC, Sharp HR, 2009 Re: Guidelines for the management of idiopathic epistaxis in adults: how we do it. Clin Otolaryngol 34(3):256-7. PMID: 19531182

    41. Fleming JC, Moorthy R. Weighill J, 2009. Recurrent neck mass following complete excision of a benign lesion (abstract). J Laryngol Otol 123(9):E18

    42. Rivzi FA, Fleming J, Solan MC, 2008. Technical notes and tips: spreading the feet for bilateral surgery. Ann R Coll Surg 90(2):165. Doi: 10.1308/003588408X261852e

    43. Fleming JC, McGregor AH, 2005. Forearm muscle profiles in tennis players. Iso Ex Sci 13:147-151. ISSN: 0959-3020

    44. Fleming JC, 2003. Health information on the Internet, JRSH 123(1):10-11. PMID: 12722578

    Book Chapters

    1. Fleming JC, Hackman TG. “Tonsillectomy”. In: Atlas of Head and Neck Surgery (ed. Simo RS, Pracy P, Fernandes R). In press; Springer Publishing, 2022. 

    2. Fleming JC. “Oral Cavity SCC”. In: Advanced ENT training: a guide to passing the FRCS (ORL-HNS) examination (ed. Manjaly J &  Kullar P). CRC Press, 2019

    3. “Nasopharyngeal SCC”. In: Advanced ENT training: a guide to passing the FRCS (ORL-HNS) examination (ed. Manjaly J &  Kullar P). CRC Press, 2019

    4. “Post-operative laryngectomy care”. In: Advanced ENT training: a guide to passing the FRCS (ORL-HNS) examination (ed. Manjaly J &  Kullar P). CRC Press, 2019

    5. “Penetrating neck trauma”. In: Advanced ENT training: a guide to passing the FRCS (ORL-HNS) examination (ed. Manjaly J &  Kullar P). CRC Press, 2019